Deep Brain Stimulation for Parkinson Disease

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Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease.

OBJECTIVES The oscillation model of Parkinson disease (PD) states that, in the subthalamic nucleus (STN), increased θ (4-10 Hz) and β (11-30 Hz) frequencies were associated with worsening whereas γ frequencies (31-100 Hz) were associated with improvement of motor symptoms. However, the peak STN frequency in each band varied widely from subject to subject. We hypothesized that STN deep brain sti...

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Current Topics in Deep Brain Stimulation for Parkinson Disease

There is a long history of surgical treatment for Parkinson disease (PD). After pioneering trials and errors, the current primary surgical treatment for PD is deep brain stimulation (DBS). DBS is a promising treatment option for patients with medically refractory PD. However, there are still many problems and controversies associated with DBS. In this review, we discuss current issues in DBS fo...

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Connectivity Predicts deep brain stimulation outcome in Parkinson disease.

OBJECTIVE The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connectivity can predict outcome in patients remain unknown. Here, we identify the structural and functional connectivity profile of effective DBS to the subthalamic nucleus (STN) and test its ability to p...

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Adaptive Deep Brain Stimulation In Advanced Parkinson Disease

OBJECTIVE Brain-computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene and ameliorate their effects in disease states. Here, we provide proof-of-principle of this approach by using a BCI to interpret pathological brain activity in patients with advanced Parkinson disease (PD) and to use this feedback to control when therapeutic deep brain s...

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Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease.

BACKGROUND Deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) has been reported to relieve motor symptoms and levodopa-induced dyskinesia in patients with advanced Parkinson disease (PD). Although it has been suggested that stimulation of the STN may be superior to stimulation of the GPi, comparative trials are limited. OBJECTIVE To extend our rand...

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ژورنال

عنوان ژورنال: Journal of Nihon University Medical Association

سال: 2014

ISSN: 0029-0424,1884-0779

DOI: 10.4264/numa.73.100